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鍏充簬娉涘彂鎬ц創鐤卞瀷閾跺睉鐥咃紙<\/b>GPP锛�<\/b><\/p> \n

GPP 鏄竴绉嶇綍瑙佺殑銆佸鍙戞€ф垨鎸佺画鍙戜綔鐨勪弗閲嶇毊鑲ょ柧鐥�[1],[2]<\/sup>锛屼复搴婁笂涓庢枒鍧楃姸閾跺睉鐥呬笉鍚�[4],[5]<\/sup>銆侴PP鏄敱涓€х矑缁嗚優锛堜竴绉嶇櫧缁嗚優锛夊湪鐨偆涓Н鑱氬紩璧风殑锛屼細鍦ㄥ叏韬箍娉涚垎鍙戠柤鐥涙€х殑鏃犺弻鎬ц創鐤�[4],[5]<\/sup>銆侴PP鎮ｈ€呯殑涓村簥鐥呯▼鍚勪笉鐩稿悓锛屾湁浜涙偅鑰呭彲鍙嶅鍙戜綔锛岃€屽彟涓€浜涙偅鑰呭垯琛ㄧ幇涓虹柧鐥呮寔缁瓨鍦ㄤ笖闂存瓏鎬у彂浣�[4]<\/sup>銆傝櫧鐒禛PP鍙戜綔鐨勪弗閲嶇▼搴﹀悇涓嶇浉鍚岋紝浣嗚嫢涓嶅強鏃舵不鐤楋紝鍙兘浼氬嚭鐜拌触琛€鐥囧拰澶氱郴缁熷櫒瀹樿“绔瓑骞跺彂鐥囷紝鍙兘浼氬嵄鍙婄敓鍛�[5]<\/sup>銆傝繖绉嶆參鎬у叏韬€х柧鐥呬細瀵规偅鑰呯殑鐢熸椿璐ㄩ噺浜х敓閲嶅ぇ褰卞搷锛屽苟澧炲姞鍖荤枟璐熸媴[11]<\/sup>銆侴PP鍦ㄤ笉鍚屽尯鍩熺殑鎮ｇ梾鐜囧悇涓嶇浉鍚岋紝濂虫€ф偅鑰呭浜庣敺鎬ф偅鑰�[5],[11],[12],[13],[14]<\/sup>銆傚浜庤兘澶熷揩閫熻В鍐矴PP鍙戜綔鐥囩姸骞惰兘鍑忓皯澶嶅彂锛屼笖鍏锋湁鍙帴鍙楃殑瀹夊叏鎬х殑鐤楁硶瀛樺湪鐫€楂樺害鏈弧瓒崇殑闇€姹�[2],[6]<\/sup>銆侴PP鐨勫彂浣滃彲瀵艰嚧浣忛櫌骞跺彲鑳藉彂鐢熶弗閲嶅苟鍙戠棁锛屽寘鎷績鍔涜“绔€佽偩琛扮鍜岃触琛€鐥囷紝鑰岀柧鐥呭彂浣滅殑涓嶅彲棰勬祴鎬у拰涓ラ噸绋嬪害鏋佸ぇ鍦板奖鍝嶄簡鎮ｈ€呯殑鐢熸椿璐ㄩ噺[5],[6]<\/sup>銆�<\/p> \n

鍏充簬鍦ｅ埄鍗�<\/b>®<\/sup><\/b>瀹舵棌<\/b><\/p> \n

鍦ｅ埄鍗�®<\/sup><\/b>瀹舵棌锛堥€氱敤鍚嶏細浣╃储鍒╁崟鎶楋級鍖呭惈闈欒剦娉ㄥ皠鍒跺墏鍜岀毊涓嬫敞灏勫埗鍓傦紝鏄竴娆炬柊鍨嬩汉婧愬寲閫夋嫨鎬ф姉浣擄紝鍙樆鏂櫧浠嬬礌-36鍙椾綋 (IL-36R)鐨勬縺娲汇€侷L-36閫氳矾鏄厤鐤郴缁熷唴鐨勪竴绉嶄俊鍙烽€氳矾锛屽凡琚瘉鏄庝笌GPP绛夊绉嶈嚜韬値鐥囨€х柧鐥呯殑鍙戠梾鏈哄埗鏈夊叧[5],[7],[8]<\/sup>銆備僵绱㈠埄鍗曟姉闈欒剦娉ㄥ皠鍒跺墏宸茶幏寰楀寘鎷編鍥姐€佹棩鏈€佷腑鍥藉拰娆х洘绛夊鍥界洃绠℃満鏋勬壒鍑嗭紝鐢ㄤ簬娌荤枟鎴愪汉GPP鍙戜綔銆�<\/p> \n

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[1] Lebwohl M et al. Spesolimab for the prevention of generalized pustular psoriasis (GPP) flares: Results from the randomized, placebo-controlled trial Effisayil 2. Abstract presented at the 25th World Congress of Dermatology July 2023, Singapore.<\/span><\/p> <\/td> \n <\/tr> \n

[2] Kharawala S, et al. The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Exp Rev Clin Immunol. 2020;16(3):239-252.<\/span><\/p> <\/td> \n <\/tr> \n

[3] Bachelez, H. Pustular psoriasis: the dawn of a new era. Acta Derm Venereol. 2020;100(3):adv000343<\/span><\/p> <\/td> \n <\/tr> \n

[4] 銆婃垜鍥芥硾鍙戞€ц創鐤卞瀷閾跺睉鐥呯殑鎮ｇ梾鐜囧拰鐤剧梾璐熸媴璋冩煡锛氫竴椤瑰熀浜庡叏鍥�2012-2016骞村煄闀囧尰鐤椾繚闄╂暟鎹殑浼扮畻銆嬶紝涓崕鍖诲浼氱浜屽崄涓冩鍏ㄥ浗鐨偆鎬х梾瀛﹀鏈勾浼氾紝2021骞�6鏈�<\/span><\/p> <\/td> \n <\/tr> \n

[5] Navarini AA, et al. European consensus statement on phenotypes of pustular psoriasis. JEADV. 2017;31:1792-1799.<\/span><\/p> <\/td> \n <\/tr> \n

[6] Crowley JJ, et al. A brief guide to pustular psoriasis for primary care providers, Postgraduate Medicine. 2021;133(3):330-344.<\/span><\/p> <\/td> \n <\/tr> \n

[7] Puig L, Choon SE, Gottlieb AB, et al. Generalized pustular psoriasis: a global Delphi consensus on clinical course, diagnosis, treatment goals, and disease management. J Eur Acad Dermatol Venereol. 2023 Jan 6. doi: 10.1111\/jdv.18851.<\/span><\/p> <\/td> \n <\/tr> \n

[8] Furue K, et al. Highlighting Interleukin-36 Signalling in plaque psoriasis and pustular psoriasis. Acta Derm Venereol. 2018;98:5鈥�13.<\/span><\/p> <\/td> \n <\/tr> \n

[9] Bachelez H, et al. Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis. N Engl J Med. 2019; 380:981-983.<\/span><\/p> <\/td> \n <\/tr> \n

[10] Lebwohl M et al. Spesolimab for the prevention of generalized pustular psoriasis (GPP) flares: Results from the randomized, placebo-controlled trial Effisayil 2. Abstract presented at the 25th World Congress of Dermatology July 2023, Singapore.<\/span><\/p> <\/td> \n <\/tr> \n

[11] Hanna M, et al. Economic burden of generalized pustular psoriasis and palmoplantar pustulosis in the United States. Curr Med Res Opin. 2021. 37(5):735-742.<\/span><\/p> <\/td> \n <\/tr> \n

[12] Augey F, et al. Generalized pustular psoriasis (Zumbusch): a French epidemiological survey. Eur J Derm. 2006; 16(6):669-673.<\/span><\/p> <\/td> \n <\/tr> \n

[13] Ohkawara A et al. Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background. Acta Derm Venereol. 1996 Jan;76(1):68鈥�71.<\/span><\/p> <\/td> \n <\/tr> \n

[14] Jin H, et al. Clinical features and course of generalized pustular psoriasis in Korea. J Dermatol. 2015; 42(7):674-678.<\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div> \n

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