[<\/b>缂栬€呮敞<\/b>]<\/b><\/p> \n

1. TLR4<\/b>鍜�<\/b>Eritoran<\/b>锛�<\/b>E5564<\/b>锛夌畝浠�<\/b><\/p> \n

TLR锛圱oll鏍峰彈浣擄級鏄厛澶╁厤鐤郴缁熺殑鍙椾綋锛屽苟鍙瘑鍒梾鍘熶綋鐨勭壒瀹氬垎瀛愮粨鏋勩€傜爺绌惰涓猴紝鐢盩LR鍚姩婵€娲荤殑鍏堝ぉ鍏嶇柅绯荤粺鍦ㄦ秷闄ょ梾鍘熶綋銆佸紩璧风値鐥囧弽搴旀垨鎶楃梾姣掑弽搴斾腑璧峰叧閿綔鐢ㄣ€俆LR4鏄疶LR锛堟瀯鎴愬悇绉嶅彈浣撳鏃忥級瀹舵棌涓殑涓€鍛橈紝鍙缁嗚弻閲婃斁鐨勮剛澶氱硸绛夊唴姣掔礌婵€娲汇€侲ritoran鏄疎isai鍏徃鍐呴儴閫氳繃澶╃劧浜х墿鏈夋満鍚堟垚鎶€鏈彂鐜板苟寮€鍙戠殑TLR4鎷姉鍓傘€傚畠鏄被鑴侫鐨勭粨鏋勭被浼肩墿锛岀被鑴侫鏄唴姣掔礌鐨勬椿鎬ц嵂鏁堟垚鍒嗐€傚湪14椤逛复搴婄爺绌讹紙鍖呮嫭涓€椤瑰湪閲嶅害鑴撴瘨鐥囦腑杩涜鐨勫ぇ鍨婭II鏈熼殢鏈鸿瘯楠岋級涓紝鏃㈠線瑙傚療鍒拌鎶楃粨鍓傚叿鏈夎€愬彈鑹ソ鐨勫畨鍏ㄦ€х壒寰併€傚湪灏忛紶娴佹劅鐥呮瘨鎰熸煋妯″瀷涓紝Eritoran鍏锋湁鎶戝埗缁嗚優鍥犲瓙浜х敓鍜屾敼鍠勫叏韬姸鍐电殑浣滅敤^{[1]<\/sup>銆傞鏈熷彲閫氳繃鎶戝埗TLR4鐨勬縺娲绘潵鎶戝埗COVID-19[2<\/sup>锛�<\/sup>3]<\/sup>寮曡捣鐨勭値鐥囧拰鎭跺寲锛汿LR4鏄紩璧风粏鑳炲洜瀛愰鏆寸殑鍚勭缁嗚優鍥犲瓙鍩哄洜琛ㄨ揪淇″彿浼犻€掔殑鏈€涓婃父銆�<\/p> \n}

鍦ㄤ腑搴OVID-19浣忛櫌鎮ｈ€呯殑鍥介檯璇曢獙REMAP-COVID涓紝宸查€夋嫨Eritoran浣滀负鍊欓€夋不鐤楄嵂鐗┿€�<\/p> \n

2. FKN<\/b>鍜�<\/b>E6011<\/b>绠€浠�<\/b><\/p> \n

FKN锛坒ractalkine锛夋槸涓€绉嶅叿鏈夌粏鑳炶縼绉昏皟鑺傚拰缁嗚優绮橀檮鍙岄噸鍔熻兘鐨勮秼鍖栧洜瀛愶紝鍦ㄧ値鐥囪繃绋嬩腑璇卞琛€绠″唴鐨粏鑳炪€侳KN鍙椾綋锛圕X3CR1锛変富瑕佸湪鍗曟牳缁嗚優銆佸法鍣粏鑳炲拰鏉€浼ゆ穻宸寸粏鑳炰腑閫夋嫨鎬ц〃杈撅紝鍦ㄥ皢鐩稿叧缁嗚優楂樻晥鍕熼泦鍒扮値鐥囬儴浣嶆柟闈㈣捣鍏抽敭浣滅敤銆傛湁鎰忚璁や负锛孎KN-CX3CR1绯荤粺涓庡绉嶆參鎬х値鐥囨€х柧鐥呮湁鍏筹紝鍖呮嫭鐐庣棁鎬ц偁鐥呫€佺被椋庢箍鎬у叧鑺傜値銆佽倽鑴忕柧鐥呫€佷腑鏋㈢缁忕郴缁熺柧鐥呫€佸姩鑴夌‖鍖栥€佺毊鑲ょ梾绛夈€侲6011鏄敱KAN Research Institute, Inc.锛圗isai鐨勭爺绌跺瓙鍏徃锛夊紑鍙戠殑浜烘簮鍖�<\/span>鎶桭KN鍗曞厠闅嗘姉浣擄紝涓庣幇鏈夌粏鑳炲洜瀛愭不鐤椾笉鍚岋紝E6011鍏锋湁鏂颁綔鐢ㄦ満鍒讹紝鍗抽€氳繃涓拰fractalkine锛團KN锛夋椿鎬ф潵鎶戝埗缁嗚優渚佃銆傜洰鍓嶏紝EA pharma Co., Ltd.锛圗isai鐨勮儍鑲犵柧鐥呭瓙鍏徃锛夋鍦ㄥ厠缃楁仼鐥呮偅鑰呬腑寮€灞曚竴椤笽I鏈熶复搴婅瘯楠屻€侲6011鍙姂鍒禖D16+鍗曟牳缁嗚優锛圕X3CR1楂樿〃杈剧殑缁嗚優缇わ紝瀵瑰眬閮ㄧ値鐥囧弽搴旇捣閲嶈浣滅敤锛変笌琛€绠″唴鐨粏鑳炵揣瀵嗙粨鍚�^{[4]<\/sup>銆傚洜姝わ紝棰勬湡E6011鍙姂鍒禖OVID-19涓殑琛€绠＄梾鍙樼殑鍙戠敓鍜屾伓鍖�[5]<\/sup>銆�<\/p> \n}

^{[1]<\/sup> KA Shirey et al., Nature<\/i>.2013 <\/b>May 23; 497(7450):498-502
[2]<\/sup> P Mehta et al., The Lancet<\/i> 2020<\/b>; 395: 1033-1034
[3]<\/sup> C Huang et al., The Lancet<\/i> 2020<\/b>; 395: 497-506
[4]<\/sup> Y Kuboi et al., Int Immunol.<\/i> 2019 <\/b>Apr 26;31(5):357
[5]<\/sup> H Li et al., The Lancet<\/i> 2020<\/b>; 395: 1517-1520<\/p>"]; $("#dvExtra").html(content_array[0]);})();}