鍏充簬<\/span><\/b>Bavituximab<\/b><\/p> \n

Bavituximab <\/span>鏄�<\/span>OncXerna<\/span>鍦ㄧ爺鎶椾綋鑽墿锛屾棬鍦ㄩ€氳繃鎶戝埗纾疯剛閰颁笣姘ㄩ吀锛�<\/span>PS<\/span>锛変俊鍙蜂紶瀵兼潵閫嗚浆鍏嶇柅鎶戝埗銆傚叕鍙哥洰鍓嶆鍦ㄥ紑灞�<\/span>Bavituximab<\/span>閽堝鏅氭湡鑳冪檶鐗瑰畾鎮ｈ€呬簹缇ょ殑涓村簥<\/span>2<\/span>鏈熻瘯楠岋紝鐢ㄤ互鎻愬崌浠栦滑瀵规姉<\/span>PD-1<\/span>娌荤枟鐨勫弽搴斻€�<\/span>Bavituximab<\/span>鐨勪綔鐢ㄦ満鍒舵槸闃绘柇浠�<\/span>PS<\/span>鍒板涓厤鐤粏鑳炲彈浣擄紙渚嬪<\/span>TIM<\/span>鍜�<\/span>TAM<\/span>锛夌殑鑲跨槫鍏嶇柅鎶戝埗淇″彿浼犲锛屽叾闈跺悜鐨勬樉鎬х敓鐗╁鐗瑰緛鍙兘涓庡绉嶇被鍨嬪疄浣撶槫鎮ｈ€呯浉鍏筹紝杩欎簺鎮ｈ€呯殑鍏嶇柅绯荤粺琚繃搴︽姂鍒讹紝鍥犺€屾棤娉曚粠鐜版湁鐨勫厤鐤偪鐦ゆ不鐤椾腑鑾风泭銆�<\/span>OncXerna<\/span>鐨勪复搴婅瘯楠屽皢<\/span>Bavituximab<\/span>涓�<\/span>Keytruda<\/span>锛堝笗鍗氬埄鐝犲崟鎶楋級缁撳悎浣跨敤锛屾棬鍦ㄦ楠岃В闄ゅ厤鐤姂鍒惰兘鍚︽彁鍗囨偅鑰呭妫€鏌ョ偣鎶戝埗鍓傜殑鍙嶅簲銆�<\/span>Bavituximab<\/span>鏄竴绉嶇爺绌舵€ц嵂鐗╋紝鐩墠灏氭湭鍦ㄥ叏鐞冧换浣曞湴鏂硅幏寰楄鍙垨鎵瑰噯锛屽苟涓斿皻鏈瘉鏄庡叾瀵逛簬浠讳綍娌荤枟鐢ㄩ€旓紙鍖呮嫭鏅氭湡鑳冪檶娌荤枟锛夌殑瀹夊叏鎬ф垨鏈夋晥鎬с€�<\/span><\/p> \n

鍏充簬<\/span><\/b>Navicixizumab<\/b><\/p> \n

Navicixizumab<\/span>鏄竴绉嶆姉<\/span>DLL4 \/ VEGF<\/span>鍙岀壒寮傛€ф姉浣擄紝涓村簥<\/span>1a \/ b<\/span>鏈熻瘯楠�<\/span>鏄剧ず<\/span>鍦ㄦ帴鍙楄繃<\/span>Avastin<\/span>锛堣礉浼愬崟鎶楋級娌荤枟鏃犳晥鐨勬偅鑰呬汉缇や腑<\/span>鏈夋姉鑲跨槫娲绘€с€傜編鍥介鍝佽嵂鍝佺洃鐫ｇ鐞嗗眬锛�<\/span>FDA<\/span>锛夊凡鎺堜簣<\/span>Navicixizumab<\/span>蹇€熼€氶亾锛�<\/span>Fast Track<\/span>锛夎瀹氾紝鐢ㄤ簬娌荤枟姝ゅ墠鎺ュ彈杩囪嚦灏�<\/span>3<\/span>绉嶇枟娉曪紝鏃犺鏄惁鎺ュ彈杩�<\/span>Avastin<\/span>娌荤枟鐨勯珮鍒嗙骇鍗靛发鐧屻€佸師鍙戞€ц吂鑶滅檶鎴栬緭鍗电鐧屾偅鑰呫€�<\/span>OncXerna<\/span>鐩墠涓昏閽堝鍏舵樉鎬ц偪鐦ょ敓鐗╁鐗瑰緛鐢辫绠＄敓鎴愰┍鍔ㄧ殑鎮ｈ€咃紝鍏朵腑閲嶇偣涓嶄粎鍖呮嫭<\/span>VEGF<\/span>锛岃繕娑电洊鏇村箍娉涚殑鎶楄绠＄敓鎴愰€氳矾銆�<\/span>Navicixizumab<\/span>鏄竴绉嶇爺绌舵€ц嵂鐗╋紝鐩墠灏氭湭鍦ㄥ叏鐞冧换浣曞湴鏂硅幏寰楄鍙垨鎵瑰噯锛屽苟涓斿皻鏈瘉鏄庡叾瀵逛簬浠讳綍娌荤枟鐢ㄩ€旓紙鍖呮嫭鏅氭湡鍗靛发鐧屾不鐤楋級鐨勫畨鍏ㄦ€ф垨鏈夋晥鎬с€�<\/span><\/p> \n

鍏充簬<\/span><\/b>OncXerna Therapeutics<\/b><\/p> \n

OncXerna 锛堥紟鑸尰鑽級閫氳繃瀵逛互RNA涓哄熀纭€鐨勮偪鐦ゅ井鐜鐨勬樉鎬х敓鐗╁鐗瑰緛鑰屽墠鐬绘€х殑璇嗗埆鐥呬汉鐨勬繁鍏ヤ簡瑙ｏ紝鑷村姏涓烘洿澶氱檶鐥囨偅鑰呭甫鏉ユ柊涓€浠ｇ簿鍑嗘不鐤楄嵂鐗┿€備负鎮ｈ€呯簿鍑嗗尮閰�<\/span>OncXerna涓村簥闃舵鑽墿锛屼互鍙婄洿鎺ヨВ鍐崇浉鍏崇敓鐗╁闂鐨勫凡鐭ヤ綔鐢ㄦ満鍒讹紝浠庤€屾樉钁楁彁鍗囩浉鍏崇檶鐥囩殑涓村簥娌荤枟缁撴灉銆傝璁块棶鍏徃缃戠珯 <\/span>oncxerna.com\/<\/a><\/span><\/u><\/p> \n

鍏充簬<\/span><\/b>OncXerna <\/b>鐨�<\/span><\/b>RNA<\/b>鐢熺墿鏍囧織鐗╁钩鍙�<\/span><\/b><\/p> \n

鐜版湁绮惧噯鑽墿浠呬綔鐢ㄤ簬澶х害<\/span>10%銆佹嫢鏈夊凡鐭ュ熀鍥犵獊鍙樻垨灏戞暟宸茬煡鑷寸檶椹卞姩鍩哄洜鐨勭檶鐥囥€�<\/span>OncXerna鑷村姏閫氳繃鍏徃涓撴湁鐢熺墿鏍囧織鐗╁钩鍙帮紝鍑€熷叾瀵�<\/span>RNA灞傞潰鑲跨槫鐢熺墿瀛︾殑娣卞埢鐞嗚В锛岀簿鍑嗚瘑鍒偅鑰呯檶鐥囩殑鏄炬€х敓鐗╁鐗瑰緛銆�<\/span>OncXerna棣栦釜鐢熺墿鏍囧織鐗╂寚鏍囦笓闂ㄩ拡瀵硅偪鐦ゅ井鐜锛�<\/span>TME Panel-1锛夛紝鍏跺垵姝ョ粨鏋滄彮绀轰簡<\/span>4绉嶄笉鍚岀殑鏄炬€х敓鐗╁鐗瑰緛锛岃瘉鏄庝簡鐗瑰畾鎮ｈ€呬簹缁勭殑瀛樺湪鍙婂叾瀵圭浉鍏虫不鐤楃殑棰勬祴浠峰€笺€�<\/span>OncXerna姝ｄ笌鍖呮嫭缇庡浗鑾彶鐗圭檶鐥囦腑蹇冨湪鍐呯殑鍚堜綔浼欎即寮€灞曠爺绌跺悎浣滐紝瀵瑰叾鐢熺墿鏍囧織鐗╁钩鍙扮殑鑲跨槫寰幆澧冩寚鏍囪繘琛屾寔缁紭鍖栥€�<\/span><\/p> \n

鍥剧墖 - https:\/\/photos.prnasia.com\/prnh\/20200918\/2921605-1?lang=1<\/a> <\/span><\/p> \n

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